4 edition of Investigation of regio- and sterochemistries of microbial biotransformation found in the catalog.
|Statement||by Mirjana Zabic.|
|The Physical Object|
|Pagination||131  leaves :|
|Number of Pages||131|
Keywords:Metabolism, acyl glucuronides, mass spectrometry, microbial bioreactor, fungal biotransformation, hepatocytes, microsomes, oxidative metabolites. Abstract: BMS is a γ-secretase inhibitor that has the potential for treatment of Alzheimer ’ s disease. The metabolism of [14C]BMS was investigated in human liver microsomes. Plant Biotransformation is the use of plants as a catalyst for specific conversion of complex substrates. One use of this biotransformation is to clone and over express genes in key enzymes. These.
Microbial biotransformation of diverse pollutants is a renewable way to clean up contaminated ambiance. These bioremediation and biotransformation methods tack the naturally acquiring, microbial catabolic diversity to reduce, transform or accumulate a enormous range of compounds including hydrocarbons polyaromatic hydrocarbons (PAHs), pharmaceutical substances, and metals etc. The ability of Rhodococcus rhodochrous (NCIMB ) to catalyse the regio- and stereoselective hydroxylation of a range of benzyloxy-substituted heterocycles has been investigated. Incubation of 2-benzyloxytetrahydropyrans with resting cell suspensions of the organism yielded predominantly a mixture of 5-hydroxylated isomers in combined yields of up to 40%.
Biotransformations are a standard tool of green chemistry and thus are following the rules of sustainable development. In this article, we describe the most common types of reactions conducted by microorganisms applied towards synthesis of chiral terpenoid derivatives. Potential applications of obtained products in various areas of industry and agriculture are shown. microbial biotransformation for generating products of interest Living cells such as bacteria, filamentous fungi, animals, plants, algae, yeast and actinomycetes are used. Microbial cells are ideal choice for biotransformation due to certain reasons like: I. Surface-volume ratio: Microbial biotransformation has high surface-volume ratio. II.
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InvestigationofRegio-andStereochemistriesofMicrobialBiotransformation by MirjanaZabic AThesis submittedtotheDepartmentofChemistry. Investigation of regio- and sterochemistries of microbial biotransformation / By Mirjana. Zabic. Abstract. Epoxides can be hydrolyzed by fungi to produce chiral diols.
The first part of this thesis presents an investigation of the microbial hydrolysis of aziridines comparable in structure to epoxide biotransformation substrates Author: Mirjana.
Zabic. The microbial catalyzed high efficient regio-selective methyl oxidation and glycosylation were discovered, which could be provided as an alternative method to expand the structural diversity of OPTs.
Download: Download full-size image; Fig. Microbial transformation of 4 olean-type pentacyclic triterpenes (OPTs).Cited by: However, if high regio and stereochemistry of oxidation is to follow, then polar enzyme substrate interactions become of signifi- H.L.
Holland/Catalysis Today 22 () cant importance and can ultimately define the regio- and stereochemical outcome of any oxidative by: 7. Investigation of regio- and sterochemistries of microbial biotransformation / January Mirjana.
Zabic; Epoxides can be hydrolyzed by fungi to produce chiral diols. The first part of this. Investigation of the Carbon- and Sulfur-Oxidizing Capabilities of Microorganisms by Active-Site Modeling.
, DOI: /S(08) Ewa Brzezowska, Jadwiga Dmochowska-Gładysz, Teresa Kołek. Biotransformation XXXIX. Microbial biotransformation is widely used in the transformation of various pollutants or a large variety of compounds including hydrocarbons, pharmaceutical substances and metals.
7 These transformations can be congregated under the categories: oxidation, reduction, hydrolysis, isomerisation, condensation, formation of new carbon bonds, and. Microbial biotransformation is a pertinent strategy to overcome difficulties and problems arising from the chemical synthesis, in order to have access to regiospecific and stereospecific compounds.
Biotransformation of Monoterpenoids by Microorganisms, Insects, and Mammals. , Investigation of the Carbon- and Sulfur-Oxidizing Capabilities of Microorganisms by Active-Site Modeling. Models for the regiochemistry and stereochemistry of microbial.
Microbial Baeyer- Villiger’s oxidation is highly regio- and stereoselective [4,] and as result it is commonly utilized for the biotransformation of steroidal compounds. It has also been shown in various studies, the ability of microbial BVMOs to attack the different ring systems of the steroid skeleton.
The microbial hydroxylation is known to be regio and enantioselective and the use of biocatalysts makes it possible to introduce the hydroxyl function to unactivated carbon atoms. The hydroxylation potential of filamentous fungi has been applied by the pharmaceutical industry to develop products such as hydroxylated flavonoids [ 20, 21 ] and.
Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids.
They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo. Another interesting use of microorganisms is for studying the metabolism of drugs and other chemicals.
Smith and Rosazza, in the early s, established the use of microbial models of mammalian metabolism (2, 3). It has been demonstrated that the microbial biotransformation system is very similar to the mammalian phase I metabolic reactions.
Microbial Processes and Products, edited by José Luis Barredo, Microbial Enzymes and Biotransformations, edited by José Luis Barredo, Environmental Microbiology: Methods and Protocols, edited by John F.
Spencer and Alicia L. Ragout de Spencer, Enzymes in Nonaqueous Solvents: Methods and Protocols, edited by Evgeny N. Abstract: About of steroid drugs have been identified since the research and development to steroid drugs was triggered in s. Although much progress in microbial biotransformation on steroid drugs is well-achieved, many efforts are ongoing in order to improve the efficiency of steroidal drug production as well as to degrade their derivatives.
The biotransformation of steroid compounds by microbes was reviewed by Fernandes inbut considerable progress has been made since then. Many steroids from natural sources, such as bufadienolides, possess significant anticancer activities. Thus, biotransformation has played a role in generating new and more active derivatives.
microbial biotransformation chapter in medicinal chemistry- authorSTREAM Presentation. Random screening: : The substrate is added to a large number of micro-organisms and after a given time the medium is analyzed for the presence of product.
Achieving regio-specific hydroxylation of aromatic compounds remains a major challenge in synthetic chemistry. By contrast, this transformation is readily accomplished in nature through the action of FAD-dependant monooxygenase enzymes. Here, we report the. investigation itself.
This will be a general discussion of investigations as a concern for the QC microbiology laboratory. Investigations for particular tests are Important but beyond the scope of this article (refer to Sutton for more information). We will consider the need to place each investigation in a larger frame"'!ork of laboratory.
Microbial biotransformation, one of the tools of green chemistry, is widely used in organic synthesis to cutshort number of organic intermediates in obtaining the final required compounds.
In the present study, an approach was made for preparing substituted derivatives of coumarin as therapeutic agents.
Bacterial whole cell biotransformations. Carvalho and Fonseca When the efficiency of the biotransformation is very low in the host cells or the number of side reactions affects the process, cloning and heterologous expression of the genes necessary for the biotransformation becomes neces-sary.
In a study to use soluble cytochrome P monooxy. Biotransformation of steroids 1. STEROID BIOTRANSFORMATION • Presented by: Sudha Chib (H) bt (2) 2. CONTENTS • INTRODUCTION • TYPES OF STEROIDAL TRANSFORMATION • COMMERCIAL DEVELOPMENT • FERMENTATION CONDITION OF SOME STEROIDS • ADVANTAGES • DISADVANTAGES 3.
Anaerobic growth of the bacterium strain HxN1 with n‐hexane gives nearly equal amounts of (2R,1′R)‐ and (2S,1′R)‐(1‐methylpentyl)succinate, which are formed by the radical addition of the hydrocarbon to fumarate (see scheme).The highly selective attack on the pro‐S hydrogen atom at C2 of n‐hexane is associated with inversion of the configuration at C2 during binding to fumarate.